Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report
JOURNAL OF NEUROVIROLOGY, vol.29, no.1, pp.111-115, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 29 Issue: 1
- Publication Date: 2023
- Doi Number: 10.1007/s13365-023-01114-6
- Journal Name: JOURNAL OF NEUROVIROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.111-115
- Keywords: HIV, IVIG, JC virus, Mefloquine, Mirtazapine, Progressive multifocal leukoencephalopathy
- Open Archive Collection: AVESIS Open Access Collection
- Gazi University Affiliated: Yes
Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by reactivation of the polyomavirus JC (JCV). Human immunodeficiency virus (HIV) infection is one of the leading causes of PML which has high morbidity and mortality due to the lack of a proven standard treatment. We found clinical and radiological improvement with the combination of high-dose methylprednisolone, mirtazapine, mefloquine, and IVIG in our patient who presented with neurological symptoms and had diagnosed concurrent acquired immunodeficiency syndrome (AIDS) and PML. To our knowledge, our case is the first HIV-associated PML which responded to this combination therapy.