Increased plasma homocysteine and allantoin levels in coronary artery disease: possible link between homocysteine and uric acid oxidation

ÖZKAN Y., Yardim-Akaydin S., Imren E., Torun M., Simsek B.

ACTA CARDIOLOGICA, vol.61, no.4, pp.432-439, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.2143/ac.61.4.2017305
  • Journal Name: ACTA CARDIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.432-439
  • Keywords: homocysteine, allantoin, uric acid, free radicals, oxidative stress, coronary artery diseases, ENDOTHELIAL DYSFUNCTION, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, ANTIOXIDANT CAPACITY, ASCORBIC-ACID, HEART-DISEASE, MURINE MODEL, RISK FACTOR, FOLLOW-UP, STRESS
  • Gazi University Affiliated: Yes

Abstract

Objective - Homocysteine increases the damage to the cardiovascular system in different ways, one of them is the formation of reactive oxygen species resulting from the auto-oxidation of homocysteine. At the same time, uric acid is one of the major antioxidants in the plasma and protects the cells towards increased ROS activity. In humans, allantoin is only formed from non-enzymatic oxidation of uric acid by free radicals. We aimed to determine the levels of homocysteine, uric acid and allontoin in patients with coronary artery diseases, and to evaluate the possible correlation between homocysteine and allantoin.