The anti-cancer efficacies of diffractaic, lobaric, and usnic acid: In vitro inhibition of glioma

Emsen B., Aslan A., Turkez H., Joughi A. T., Kaya A.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.14, no.5, pp.941-951, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.4103/0973-1482.177218
  • Journal Name: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.941-951
  • Keywords: Cytotoxicity, genotoxicity, glioblastoma multiforme, lichen, oxidative status, secondary metabolite, SECONDARY METABOLITES, OXIDATIVE STRESS, ANTIPROLIFERATIVE ACTIVITIES, ANTIOXIDANT ACTIVITY, CYTOTOXIC ACTIVITIES, LICHEN COMPOUNDS, PROTECTIVE ROLE, CELL-LINES, ANTIBACTERIAL, EXTRACT
  • Gazi University Affiliated: No

Abstract

Aims: Glioblastoma multiforme (GBM) shows the most aggressive invasion among primary brain tumors. In spite of the standard therapy methods such as surgery, radiotherapy, and chemotherapy, the mortalities are high in GBM patients owing to side effects. Some lichen secondary metabolites that have many bioactive functions exhibited anti-cancer efficacy toward many cancer types. The present study was undertaken to investigate proliferation change, oxidative status and DNA damage potentials of human U87MG-GBM, and primary rat cerebral cortex (PRCC) cells exposed to three lichen secondary metabolites.