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12/29/2020

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Recent Publications

<i>In silico</i> approach reveals <i>N</i>-(5-phenoxythiophen-2-yl)-2-(arylthio)acetamides as promising selective SIRT2 inhibitors: the case of structural optimization of virtual screening-derived hits

GÖZELLE M., BAKAR ATEŞ F., Massarotti A., Ozkan E., Gunindi H. B., ÖZKAN Y., et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023 (SCI-Expanded)

Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy

KAYA S. G., EREN G.
BIOORGANIC CHEMISTRY, vol.143, pp.107038-0, 2024 (SCI-Expanded)

Field-based 3D-QSAR studies on amide- and urea-containing NAMPT inhibitors

ÖZGENCİL F., EREN G.
Chemometrics and Intelligent Laboratory Systems, vol.242, 2023 (SCI-Expanded)

3D-QSAR Studies on Amide and Urea Derivatives as NAMPT Inhibitors

ÖZGENCİL F., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022

In Silico Hit Optimization toward SIRT2 Inhibition: N-aryloxyaryl-2-(arylthio)acetamides

KAYA S. G., ÖZKAN Y., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022

N-(5-(3-Methoxybenzyl)/(pyrimidin-2-yl-methyl))-1,3,4-oxadiazol-2-yl)-2-(arylthio)acetamide Derivatives as SIRT2 Inhibitors

AKSEL A. B., ÖZKAN Y., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022

Ariloksi Benzamit Yapısında Sirtuin İnhibitörü Olabilecek Bileşiklerin Tasarımı, Sentezi ve Biyolojik Aktivite Çalışmaları

YAĞCI S., GÖZELLE M., ÖZKAN Y., BAKAR ATEŞ F., EREN G.
VI. Ulusal Farmasötik Kimya Kongresi, İstanbul, Turkey, 26 - 29 August 2022

Yeni Nikotinamit Fosforiboziltransferaz (NAMPT) İnhibitör Adaylarının Sanal Tarama Yöntemi ile Keşfi ve Biyolojik Etkilerinin Belirlenmesi

ÖZGENCİL F., ÖZKAN Y., EREN G.
VI. Ulusal Farmasötik Kimya Kongresi, İstanbul, Turkey, 26 - 29 August 2022

Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity

Gözelle M., Kaya S. G., Aksel A. B., Özkan E., Bakar Ateş F., Özkan Y., et al.
Bioorganic Chemistry, vol.123, pp.105746, 2022 (SCI-Expanded)

Discovery of 5-Benzyl-1,3,4-oxadiazole/thiadiazole-2-carboxamides as Potential Leads for Selective SIRT2 Inhibition

GÖZELLE M., ÖZKAN Y., EREN G.
GPSS-2021, 3rd International Gazi Pharma Symposium Series, Ankara, Turkey, 8 - 10 September 2021