Retrospective evaluation of routine biochemical blood parameters in children with autism

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Gök Dağıdır H., Bukan N., Arhan E., Tombul N., Arslan B., Ülgen Temel E.

GEVHER NESIBE 4. ULUSLAR ARASI SAGLIK BILIMLERI KONGRESI, Ankara, Türkiye, 23 - 24 Kasım 2019, ss.229-233

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.229-233
  • Gazi Üniversitesi Adresli: Evet

Özet

Autism spectrum disorder (ASD); It is an extremely heterogeneous neurodevelopmental disorder that occurs in early childhood, characterized by lack of social interaction and communication, sensory differences, limited interests, and stereotypical repetitive rigid behavior patterns.

The estimated global prevalence of autism spectrum disorder (ASD) is approximately 1.0%.

Although the number of cases of Autism Spectrum Disorders (ASD) diagnosed during the last four decades has increased significantly, there is still considerable debate about the underlying pathophysiology of ASD.

The aim of this retrospective study was to evaluate the biochemical blood parameters of children with autism.

The study included 30 children with autism aged between 10 and 18 years and 30 healthy children as a control group. The autism group was selected from the children with autism diagnosis in the Department of Pediatric Neurology at Gazi University Faculty of Medicine between 2018-2019 and the control group was selected from the Children's Health Unit. In two groups, routine biochemical parameters were evaluated retrospectively.

According to the study, the ratio of boys to girls was 1,5 in children with autism and 0,87 in the control group. Although vitamin 25-OHD levels were low in both autism and control groups, the difference was statistically significant p = 0.025. and vitamin 25-OHD levels in the autism group were lower than in the control group (p<0,05) . Vitamin D deficiency has recently been considered a potential environmental risk factor for ASD. Vitamin D is potent neurosteroid, which mediates numerous actions in several body tissues including brain. The difference between ALT levels of autism and control group was also statistically significant, p = 0,049 (p <0,05).

We believe that randomized controlled trials using adequate doses of vitamin D3 are necessary in children with autism, and that further studies on nutritional disorders and behavioral problems, metabolic differences, and biomarkers are necessary.