Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms

Ozkan S., Ozkan Y., Senturk Z.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.17, sa.2, ss.299-305, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0731-7085(97)00202-1
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.299-305
  • Anahtar Kelimeler: metronidazole, voltammetry, activated glassy carbon electrode, drug analysis, PERFORMANCE LIQUID-CHROMATOGRAPHY, SPECTROPHOTOMETRIC DETERMINATION, DRUGS, NITROBENZENE, VOLTAMMETRY, TINIDAZOLE, ORNIDAZOLE, BEHAVIOR
  • Gazi Üniversitesi Adresli: Hayır

Özet

A voltammetric method has been developed for the determination of metronidazole in dosage forms. The method is based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applying a new pretreatment. The influence of pH, concentration, scan rate and presence of organic solvent and surfactant has been studied. The current is proportional to the concentration and permits the drug to be determined in the concentration range 2 x 10(-6)-6 x 10(-4) M in Britton-Robinson buffer (pH 10). Furthermore, results obtained by the proposed method have been compared with USP XXIII procedure which involves a HPLC method. (C) 1998 Elsevier Science B.V. All rights reserved.