Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms


Ozkan S., Ozkan Y., Senturk Z.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol.17, no.2, pp.299-305, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1016/s0731-7085(97)00202-1
  • Journal Name: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.299-305
  • Keywords: metronidazole, voltammetry, activated glassy carbon electrode, drug analysis, PERFORMANCE LIQUID-CHROMATOGRAPHY, SPECTROPHOTOMETRIC DETERMINATION, DRUGS, NITROBENZENE, VOLTAMMETRY, TINIDAZOLE, ORNIDAZOLE, BEHAVIOR
  • Gazi University Affiliated: No

Abstract

A voltammetric method has been developed for the determination of metronidazole in dosage forms. The method is based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applying a new pretreatment. The influence of pH, concentration, scan rate and presence of organic solvent and surfactant has been studied. The current is proportional to the concentration and permits the drug to be determined in the concentration range 2 x 10(-6)-6 x 10(-4) M in Britton-Robinson buffer (pH 10). Furthermore, results obtained by the proposed method have been compared with USP XXIII procedure which involves a HPLC method. (C) 1998 Elsevier Science B.V. All rights reserved.