Anestezi Dergisi, cilt.34, sa.2, ss.77-84, 2026 (Scopus, TRDizin)
Peripheral nerve blocks have brought a new perspective to regional anesthesia following the use of neuraxial blocks. The fact that they can be administered for anesthetic and/or analgesic purposes in many situations where neuraxial blocks are contraindicated has led to a marked increase in their use. With the integration of ultrasound into routine anesthetic practice, their use has become widespread not only in adult patients but also in the paediatric age group, thanks to safe procedures with high success rates. Although they are performed with the aid of nerve monitoring techniques and monitors alongside ultrasound, it is evident that complications encountered in various systems have not been completely eliminated. Complications affecting the neurological system constitute the group that causes the most concern among clinicians. Numerous factors related to anesthesia, surgery and the patient play a role in the development of these complications. Therefore, the combined assessment of all these factors is the most significant factor influencing early diagnosis, adequate treatment and, consequently, improved prognosis. The aim of this review is to comprehensively discuss the patho-physiological and aetiological factors underlying neurological complications that may arise following a peripheral nerve block, and to offer a new perspective on strategies to prevent complications through safer regional anesthesia practices.