Discovery of potent in vitro neuroprotective effect of the seed extracts from seven Paeonia L. (peony) taxa and their fatty acid composition

Sevim D., ŞENOL DENİZ F. S., Gulpinar A. R., ERDOĞAN ORHAN İ., Kaya E., KARTAL M., ...Daha Fazla

INDUSTRIAL CROPS AND PRODUCTS, cilt.49, ss.240-246, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.indcrop.2013.05.001
  • Dergi Adı: INDUSTRIAL CROPS AND PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.240-246
  • Anahtar Kelimeler: Paeonia, Peony, Enzyme inhibition, Neuroprotection, Antioxidant activity, Fatty acid, TYROSINASE INHIBITORS, ANTIOXIDANT ACTIVITY, RESVERATROL, CHOLINESTERASE, SUFFRUTICOSA, DERIVATIVES, LACTIFLORA, STILBENES, COUMARIN, ESTERS
  • Gazi Üniversitesi Adresli: Evet

Özet

Neuroprotective effect of the seed ethanol extracts of seven Anatolian Paeonia L taxa (P. arietina, P. x kayae, P. mascula subsp. bodurii and subp. mascula, P. daurica, P. peregrina, and P. terunfolia) was determined in vitro via acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYRO) inhibition using ELISA microtiter plate assays. Their antioxidant effect was determined using 2,2diphenyl-1-picrylhydrazyl (DPPH), N,N-dimethyl-p-phenylendiamine (DMPD), and nitric oxide (NO) radical scavenging activity, metal-chelation capacity, and ferric-reducing antioxidant power (FRAP) assays. Total phenol and flavonoid quantification of the extracts was calculated spectrophotometrically. Fatty acid composition of the seed oils was also determined. The extracts displayed potent inhibition against AChE and BChE and marked TYRO inhibition, while they showed low to moderate activity in the antioxidant tests. The oils were found to have similar fatty acid compositions which are rich in oleic, linoleic, and linolenic acids, with exception the seed oil of P. mascula subsp. bodurii. (C) 2013 Elsevier B.V. All rights reserved.