The femoral artery is the most common vascular access site used for angiographic interventions. Various complications, such as hematoma, bleeding, dissection, arteriovenous fistula, and pseudoaneurysm have been described following an iatrogenic puncture. However, angiosarcoma formation at the access site is very uncommon and poses a diagnostic dilemma, due to the resemblance to an organized hematoma. A 75-year-old patient who had previously undergone coronary angiography developed angiosarcoma with vascular complications due to local invasion at the puncture site. Although the tumor was completely excised and flow was re-established, the patient died 17 months later as a result of multiple metastases and associated complications. The presence of a persistent mass with vascular complaints should raise suspicion for this rare and aggressive type of tumor.