Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.34, sa.1, ss.20-26, 2006 (Scopus)
Aim: Our aim for this study was to investigate the analgesic effect of preemptive 8 or 16 mg lornoxicam versus placebo which was applied to the patients before elective lumbar disc surgery. Materials and Methods: 60 patients who were in ASA I-II group were investigated during elective lumbar surgery. The patients were randomly evaluated in three groups. The groups were arranged as follows: At the first group (Group P) 100 mL saline solution was used, at the second group (Group L8) 8 mg lornoxicam was used and at the third group (Group L16) 16 mg lornoxicam in 100 mL saline solution was used. Intravenous 5 mg kg-1 thiopental, 0.2 μg kg-1 sec-1 remifentanil infusion and 0.1 mg kg-1 iv pancuronium bromür were used for induction of anaesthesia, and 1% concentration of isoflurane in 50% O2 50% air was used for maintenance of anaesthesia at all groups. According to the arterial blood pressure which would be held in range of preoperative value ±20%, remifentanil infusion rate was arranged. Preoperative, postoperative Aldrete≥9 period, and there alter 2-4-6-24 th hours; VAS data, peroperative total remifentanil consumption and side effects were recorded. Patients were observed at least for 1 hour at the recovery room and 24 hour at the service. One mg kg-1 im pethidine hydrochlorur was applied after the, first analgesic request of the patient (VAS≥4) and then 0.5 mg kg-1 pethidine was applied intravenously. Postoperative first additional analgesic requirement time and total pethidine hydrochlorur consumption during 24 hour was recorded. Postoperative "first analgesic requirement time" was longer at Group L16 than Group L8 and Group P. At Group L8 postoperative "first analgesic requirement time" was significantly longer then Group P. Pethidine hydrochlorur consumption during the postoperative 24 hours was evaluated significantly less in Group L16 and Group L8 then Group P (p≤0,05). Results: There was no significant difference at peroperative consumption of remifentanil between three groups. Postoperative "first analgesic requirement time" was longer at Group L16 than Group L8 and Group L8 significantly longer then Group P. During the postoperative 24 hours pethidine hydrochlorur consumption significantly less in Group L16 and Group L8 then Group P (p≤0, 05). Conclusion: Preempitive lornoxicam has postoperative analgesic effect at lumbar disc surgery. On the other hand we have concluded that when 16 mg lornoxicam is used, analgesia time is longer than 8 mg lornoxicam application.