POSSIBLE INVOLVEMENT OF EICOSANOIDS IN ALPHA-NAPHTHYLTHIOUREA-INDUCED PULMONARY-EDEMA AND ALTERATION OF ANGIOTENSIN-CONVERTING ENZYME-ACTIVITY


ERCAN Z., EREN S., ZENGIL H., TURKER R.

PHARMACOLOGY, vol.46, no.5, pp.274-280, 1993 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 5
  • Publication Date: 1993
  • Title of Journal : PHARMACOLOGY
  • Page Numbers: pp.274-280

Abstract

Alpha-naphthylthiourea (ANTU) when injected intraperitoneally to rats at a dose of 10 mg/kg elicited lung oedema indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion. The injection of acetylsalicylic acid, which is a cyclo-oxygenase inhibitor, and BW 755C, a cyclo-oxygenase and lipoxygenase inhibitor, prior to ANTU produced a significant inhibition in pleural fluid accumulation without changing the LW/BW ratio. BW A4C, a selective 5-lipoxygenase inhibitor, however, caused a highly significant inhibition in pleural effusion and a slight but significant decrease in LW/BW ratio. Thromboxane A2 synthetase inhibitor, UK 38485, caused a slight but significant inhibition in pleural fluid accumulation without altering the LW/BW ratio. Iloprost, however, produced a slight but significant inhibition in the LW/BW ratio without reducing the pleural effusion rate. A significant decrease in angiotensin-converting enzyme (ACE) activity in the isolated perfused lungs of ANTU-treated rats was noted. This observation was thought to be an evidence of a functional alteration of the lung vascular endothelium. The possible role of eicosanoids in lung oedema induced by ANTU and the related mechanisms of decreased ACE activity are discussed.