Effects of the benzodiazepine antagonist flumazenil on postoperative recovery in laparoscopy

Ozkose Z. , Celebi H., Bozkirli F.

Turk Anesteziyoloji ve Reanimasyon, cilt.22, sa.3, ss.133-136, 1994 (Diğer Kurumların Hakemli Dergileri) identifier

  • Cilt numarası: 22 Konu: 3
  • Basım Tarihi: 1994
  • Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
  • Sayfa Sayıları: ss.133-136


Forty ASA I-II patients who underwent gynaecological laparoscopy procedure have been studied in two randomly selected groups. Group I (n=20) received alfentanil (7 μg/kg), midazolam (0.2 mg/kg) and atracurium (0.5 mg/kg), while group II received (n=20) alfentanil (7 μg/kg), flunitrazepam (0.03 mg/kg) and atracurium (0.5 mg/kg) intravenously and anaesthesia was maintained with % 66/33 N2OO2 following endotracheal intubation in both groups. In postoperative period both groups were divided and studied in double blind fashion, in which placebo (% 0.9 NaCl) and titrated flumazenil were administered intravenously. Recovery were evaluated with Modified Steward and Sedation Scoring methods. In flumazenil group recovery has started at 2nd minute and reached to its maximum at 10th minute, while in placebo group recovery was not complete even at 30th minute (p<0.05). Effective mean flumazenil dose administered was 0.5 mg (5 ml). In conclusion, flumazenil has antogonized both flunitrazepam and midazolam similarly without any serious side effect.