MARRUBINONE-A AND MARRUBINONE-B, NEW LABDANE DITERPENOIDS FROM MARRUBIUM-ASTRACANICUM (LABIATAE)

IIDA A., TANAKA Y., MIHARA T., TABATA M., HONDA G., SHINGU T., ...Daha Fazla

CHEMICAL & PHARMACEUTICAL BULLETIN, cilt.43, sa.9, ss.1454-1457, 1995 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 9
  • Basım Tarihi: 1995
  • Dergi Adı: CHEMICAL & PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1454-1457
  • Anahtar Kelimeler: MARRUBIUM ASTRACANICUM, MARRUBINONE, LABDANE, DITERPENOID, MODIFIED MOSHERS METHOD, NMR, COHERENCE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Two new labdane diterpenoids, marrubinones A (1) and B (2), were isolated from aerial parts of Marrubium astracanicum collected in Turkey. Compounds 1 and 2 were mostly characterized by two-dimensional NMR. For determination of the absolute configuration, the modified Mosher's method was applied to the 12-hydroxy forms of 1 and 2. Compounds 1 and 2 are pentacyclic diterpenoids, which differ from each other only in the stereochemistry at C-13, and they were identified as 9 alpha,13S:15,16-diepoxy-12-oxo-14-labden-19,6 beta-olide and 9 alpha,13R:15,16-diepoxy-12-oxo-14-labden-19,6 beta-olide, respectively.