Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey)

Gurbuz İ., Ozkan A., Yesilada E., Kutsal O.

JOURNAL OF ETHNOPHARMACOLOGY, vol.101, no.1-3, pp.313-318, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 1-3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jep.2005.05.015
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.313-318
  • Keywords: Malva neglecta, Potentilla reptans, Rumex patientia, Sanguisorba minor ssp muricata, Sideritis caesarea, Verbascum cheiranthifolium var. cheiranthifolium, anti-ulcerogenic activity, ethanol-induced ulcerogenesis, histopathology, peptic ulcer, TRADITIONAL MEDICINE, EXTRACTS, ANATOLIA
  • Gazi University Affiliated: Yes


Several ethnomedicinal plant remedies used in Pinarbasi, Kayseri, in particular those which are used for the treatment of several peptic ulcer symptoms such as stomach ache, heartburn, etc. were selected for evaluation of their anti-ulcerogenic potential. In order to confirm the claimed activities, decoctions were prepared from aerial parts of Malva neglecta Wallr. (Malvaceae), leaves of Potentilla reptans L. (Rosaccae), fruits of Rumex patientia L. (Polygonaceae), aerial parts of Sanguisorba minor Scop. ssp. muricata (Spach) Briq. (Rosaccae), aerial parts of Sideritis caesarea Duman, Aytac&Baser (Lamiaceae), and flowers of Verbascum cheircinthifolium Boiss var. cheiranthifolium (Scrophulariaceae) according to their described folkloric applications. Pharmacological experiments clearly demonstrated that the extracts of all plants given orally showed significant gastric protection against the ethanol-induced gastric ulcer model in rats. Furthermore, healing effects were also confirmed through histopathological examination. (C) 2005 Elsevier Ireland Ltd. All rights reserved.