Effects of Topical Mitomycin-C on the Tracheal Epithelia of Rabbits following Tracheostomy.

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Çalik S. G. , Çalik M., Arslan Kaşdoğan Z. E. , Avunduk M. C. , Esme H., Aribaş O. K.

Turkish journal of medical sciences, vol.51, pp.857-863, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-1802-187
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.857-863
  • Keywords: Tracheostomy, tracheal epithelia, rabbits, mitomycin-C (MMC), SURGICAL-TREATMENT, MANAGEMENT, STENOSIS, STENTS
  • Gazi University Affiliated: Yes


Background/aim: We aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model. Materials and methods: Twenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Tracheostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC).