Evaluation of human leukocyte antigen class I and II antigens in Helicobacter pylori-positive pediatric patients with active gastritis and duodenal ulcer Avaliação de antígeno leucocitário humano classe I e II em pacientes pediátricos com gastrite e úlcera duodenal ativas e Helicobacter pylori positivo

GÖNEN S., SARI S., Kandur Y., DALGIÇ B., Söylemezoğlu O.

Arquivos de Gastroenterologia, vol.54, no.4, pp.297-299, 2017 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1590/s0004-2803.201700000-62
  • Journal Name: Arquivos de Gastroenterologia
  • Journal Indexes: Scopus
  • Page Numbers: pp.297-299
  • Keywords: Child, Duodenal ulcer, Gastritis, Helicobacter pylori, HLA antigens
  • Gazi University Affiliated: Yes


© 2017, IBEPEGE - Inst. Bras. Estudos Pesquisas Gastroent. All rights reserved.Background – As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. Objective – The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. Methods – The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. Results – The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003). There was no difference between the two groups in terms of the frequencies of HLA-A, HLA-C, HLA-DR, and HLA-DQ antigens. Conclusion – It was determined that HLA-B*51 plays a critical role in H. pylori infection.