Assessment of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in the Periodontium of Rats Treated With Atorvastatin


Balli U., KELEŞ G., ÖZKAN ÇETİNKAYA B., Mercan U., AYAS B., Erdogan D.

JOURNAL OF PERIODONTOLOGY, vol.85, no.1, pp.178-187, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1902/jop.2013.130018
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.178-187
  • Keywords: Atorvastatin, histology, immunohistochemistry, periodontal disease, rats, GINGIVAL CREVICULAR FLUID, ALVEOLAR BONE LOSS, HMG-COA REDUCTASE, MATRIX METALLOPROTEINASES, TISSUE INHIBITORS, SIMVASTATIN, EXPRESSION, MMP-9, DEFECTS, ANGIOGENESIS

Abstract

Background: The aim of this study is to examine, for the first time, the role of systemic and local atorvastatin application on periodontium using histomorphometric and immunohistochemical analysis during and after experimental periodontitis induction with or without the presence of microbial dental biofilm.