CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Laurie C., Reynolds A., Coskun Ö., Bowman E., Gendelman H. E., Mosley R. L.

Journal of Neuroimmunology, cilt.183, sa.1-2, ss.60-68, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 183 Sayı: 1-2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jneuroim.2006.11.009
  • Dergi Adı: Journal of Neuroimmunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-68
  • Anahtar Kelimeler: CD4+ T cells, Copolymer-1, Immunomodulation, MPTP, Neuroprotection, Parkinson's disease
  • Gazi Üniversitesi Adresli: Hayır

Özet

Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease. © 2006.