Intracavernous application of diazepam: An alternative route of the seizure treatment - an experimental study in rabbits

Dundaroz R., Degim T., Sizlan A., Yasar M., Denli M., Gokcay E.

PEDIATRICS INTERNATIONAL, vol.44, no.2, pp.163-167, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1328-8067.2001.01530.x
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.163-167
  • Gazi University Affiliated: No

Abstract

Backround: There is a general need to terminate seizures as soon as possible using anticonvulsant drugs via an intravenous (i.v.) route, but it is often difficult to achieve a secure i.v. Line during the seizure, especially in children. However, it has been demonstrated that high volumes of fluid can be injected into the corpora cavernosa. The purpose of this study was to evaluate the absorption properties of diazepam (DZ) after intracavernous (i.c.) administration and whether therapeutically significant plasma concentrations can be obtained or not.