Intracavernous application of diazepam: An alternative route of the seizure treatment - an experimental study in rabbits

Dundaroz R., Degim T., Sizlan A., Yasar M., Denli M., Gokcay E.

PEDIATRICS INTERNATIONAL, cilt.44, sa.2, ss.163-167, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1328-8067.2001.01530.x
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.163-167
  • Gazi Üniversitesi Adresli: Hayır

Özet

Backround: There is a general need to terminate seizures as soon as possible using anticonvulsant drugs via an intravenous (i.v.) route, but it is often difficult to achieve a secure i.v. Line during the seizure, especially in children. However, it has been demonstrated that high volumes of fluid can be injected into the corpora cavernosa. The purpose of this study was to evaluate the absorption properties of diazepam (DZ) after intracavernous (i.c.) administration and whether therapeutically significant plasma concentrations can be obtained or not.