Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons

---

Atıf İçin Kopyala

EREN G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.6, ss.727-736, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 14 Sayı: 6
• Basım Tarihi: 2017
• Doi Numarası: 10.2174/1570180814666161110112859
• Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.727-736
• Gazi Üniversitesi Adresli: Evet

Özet

Background: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that plays crucial roles in energy metabolism, DNA repair and cell death. Due to the high proliferation rate and the high energy necessity in cancer cells, NAD biosynthesis and salvage is required. Owing to the NAD importance in cancer cells, NAD salvage/recycling enzymes are targets for drug discovery.