Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons


EREN G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.6, ss.727-736, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1570180814666161110112859
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Sayfa Sayıları: ss.727-736

Özet

Background: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that plays crucial roles in energy metabolism, DNA repair and cell death. Due to the high proliferation rate and the high energy necessity in cancer cells, NAD biosynthesis and salvage is required. Owing to the NAD importance in cancer cells, NAD salvage/recycling enzymes are targets for drug discovery.