Akademik Veri Yönetim Sistemi
BMC Anesthesiology, cilt.25, sa.1, 2025 (SCI-Expanded)
Background: Sevoflurane, a commonly used inhalational anesthetic, has been associated with hepatotoxicity, although reports are often isolated. Cerium oxide nanoparticles (CeO₂) are effective free radical scavengers with potential therapeutic applications for oxidative stress-related damage. This study aimed to evaluate the protective effects of CeO₂ on liver damage in sevoflurane-administered rats. Methods: A total of 24 male Wistar albino rats were randomized into four groups: Control (C), Sevoflurane (S), Cerium Oxide (CeO₂), and Sevoflurane + Cerium Oxide (S + CeO₂). Sevoflurane was administered at 2% concentration with 100% oxygen at 4 L/min for 2 h in Groups S and S + CeO₂. CeO₂ (0.5 mg/kg) was administered intravenously in Groups CeO₂ and S + CeO₂. Biochemical analyses of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), hemoglobin (Hgb), and hematocrit (Hct) were performed, and liver tissues were examined histopathologically. Results: Hydropic degeneration and neutrophil infiltration were significantly lower in Group CeO₂ compared to Group S. Group S showed elevated AST and LDH levels compared to the control (p < 0.05). Although AST levels were lower in Groups CeO₂ and S + CeO₂ than in Group S, the difference was not statistically significant. LDH levels were significantly lower in Group S + CeO₂ compared to Group S (p = 0.045). Histopathological examination confirmed reduced liver damage in CeO₂-treated groups. Conclusions: This study is of significance since it is the first experimental study on the effect of CeO2 on liver damage caused by sevoflurane. Cerium oxide demonstrated potential in mitigating sevoflurane-induced liver damage. Further research is warranted to explore the clinical relevance of CeO₂ in hepatic injury.