The Effect of Intracerebroventricular Injection of Beta Amyloid Peptide (1-42) on Caspase-3 Activity, Lipid Peroxidation, Nitric Oxide and NOS Expression in Young Adult and Aged Rat Brain

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Cetin F., Yazıhan N., Dincer S., Akbulut G.

TURKISH NEUROSURGERY, vol.23, pp.144-150, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2013
  • Doi Number: 10.5137/1019-5149.jtn.5855-12.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.144-150
  • Keywords: Beta amyloid, Caspase 3 activity, Lipid peroxidation, Nitric oxide, Nitric oxide synthase, Hippocampus, Aging, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, INCREASES, APOPTOSIS, NEURONS, NEUROTOXICITY, HIPPOCAMPUS, GLUTATHIONE, SYSTEM
  • Gazi University Affiliated: Yes

Abstract

AIM: Intracerebroventricular (icy) administration of beta amyloid peptide (A beta) in rats can be used to model certain aspects of Alzheimer disease (AD).The purpose of this study was to examine the effects of intracerebroventricular A(3 (1-42) peptide injection on caspase-3 activity and expression of nNOS and iNOS, malondialdehyde (MDA), glutathione (GSH) and NOx in the hippocampus, temporal cortex and parietal cortex.