The emerging importance of cortical spreading depression in migraine headache

Bolay H. B., Moskowitz M.

REVUE NEUROLOGIQUE, cilt.161, ss.655-657, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 161
  • Basım Tarihi: 2005
  • Dergi Adı: REVUE NEUROLOGIQUE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.655-657
  • Anahtar Kelimeler: migraine aura, cortical spreading depression, trigeminovascular activation, matrix metalloproteinases, nitric oxide, CORTEX, PAIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Migraine is a disabling neurovascular disorder with a complex pathophysiology. Functional imaging and magneto encephalographic studies strongly suggest that Cortical Spreading Depression (CSD) constitutes the biological basis for the neurologic aura that precedes headache in one fourth of migrainers. It is likely that the aura is the generator of the headache since experimentally, CSD triggers the activation of the trigeminovascular system, possibly through matrix metalloproteases activation which is associated with an increase in vascular permeability. These data may have therapeutic implications: strategies to block trigeminal activation or its downstream consequences are central to treat the acute headache whereas strategies to block events lying upstream of trigeminal activation would be crucial in prophylaxis.