Intrauterine CRH-treated PBMC in repeated implantation failure


Makrigiannakis A., Vrekoussis T., Makrygiannakis F., Ruso H., Kalantaridou S. N. , Gurgan T.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.49, no.5, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1111/eci.13084
  • Title of Journal : EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Abstract

Background: The intrauterine administration of activated autologous peripheral blood monocytes (PBMC) prior to embryo transfer seems to improve reproductive outcomes in women with repeated implantation failure (RIF). We have previously shown that the intrauterine administration of PBMC treated with corticotropin-releasing hormone (CRH) prior to blastocyst transfer (day 5) improves significantly the clinical pregnancy rate of women with RIF. In the present crossover pilot study, we have investigated whether CRH-PBMC treatment could be of benefit in case of fresh early cleavage stage embryo transfer (day 3) in women with RIF.