Intrauterine CRH-treated PBMC in repeated implantation failure

Makrigiannakis A., Vrekoussis T., Makrygiannakis F., Ruso H., Kalantaridou S. N., Gurgan T.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.49, sa.5, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/eci.13084
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: corticotrophin-releasing hormone, implantation, in vitro fertilization, peripheral blood mononuclear cells, repeated implantation failure, CORTICOTROPIN-RELEASING HORMONE, MONONUCLEAR-CELLS PBMC, EMBRYO-TRANSFER CYCLES, ENDOMETRIAL INJURY, PREGNANCY RATES, LOCAL INJURY, IN-VITRO, PROGESTERONE, SPLENOCYTES, IMPROVES
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: The intrauterine administration of activated autologous peripheral blood monocytes (PBMC) prior to embryo transfer seems to improve reproductive outcomes in women with repeated implantation failure (RIF). We have previously shown that the intrauterine administration of PBMC treated with corticotropin-releasing hormone (CRH) prior to blastocyst transfer (day 5) improves significantly the clinical pregnancy rate of women with RIF. In the present crossover pilot study, we have investigated whether CRH-PBMC treatment could be of benefit in case of fresh early cleavage stage embryo transfer (day 3) in women with RIF.