Plants have been used as medicine by mankind to treat health-threatening diseases and still popular to develop new drug candidates. Plants have a combination of phytochemicals also known as secondary metabolites that are naturally occurred gives different therapeutic benefits. Natural products have been recognized as an important role in the drug discovery process moreover the other sources. Presently, over 100 natural product-derived pharmaceuticals are being used in modern medicine. Some of them play as important tools in the immune system exhibiting antiviral potentials. This review presents a survey of natural products and herbal extracts that have indicated broad antiviral activity.