EFFECTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ON REMOTE ORGANS IN AN EXPERIMENTAL MODEL OF INTESTINAL ISCHEMIC REPERFUSION INJURY


Alpsoy M. A. , Ozer C., Yildirim Z., Pampal A., OYAR E. Ö.

OXIDATION COMMUNICATIONS, vol.39, no.4, pp.3108-3117, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 4
  • Publication Date: 2016
  • Title of Journal : OXIDATION COMMUNICATIONS
  • Page Numbers: pp.3108-3117

Abstract

Ischemic reperfusion injury (IRI) is a dual process with local damage due to hypoxia during ischemia and additional local and systemic injury due to inflammation and oxidative damage during reperfusion. Vascular endothelial growth factor (VEGF) is a protein known to stimulate vasculogenesis and angiogenesis. It is also accepted to alleviate the effects of IRI as it has antioxidant and vasodilator properties. The aim of this study is to evaluate the remote organ effects of VEGF in an experimental model of mesenteric ischemia and reperfusion.