2-Styrylbenzimidazole derivatives, synthesis and antimicrobial activities

Tosun A., Ersan S., Uzunoglu S., BAYTAŞ S., ŞAHİN M. G., Ozden T., ...Daha Fazla

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.12, sa.1, ss.29-36, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 1995
  • Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.29-36
  • Anahtar Kelimeler: 2-(2-benzimidazolyl)-1-arylethylene, 2-methylbenzimidazole, antibacterial activity, antifungal activity
  • Gazi Üniversitesi Adresli: Evet

Özet

2-Methylbenzimidazole as a starting material has been prepared by refluxing o-phenylenediamine with glacial acetic acid in hydrochloric acid for 6 hours according to the Phillps Method. 2-Styrylbenzimidazole derivatives have been synthesized by refluxing with 2-methylbenzimidazole and p-substituted arylaldehydes in acetic anhydride for 30 hours. Antimicrobial activities of the synthesized compounds have been tested against yeast-like fungi such as Candida albicans, Candida stellatoidea, Candida parapsilosis, Candida pseudotropicalis and Gram (+) microorganisms such as Staphylococcus aureus, Bacillus subtilis and Gram (-) microorganisms such as Escherichia coli, Pseudomonas aeruginosa.