2-Styrylbenzimidazole derivatives, synthesis and antimicrobial activities

Tosun A., Ersan S., Uzunoglu S., BAYTAŞ S., ŞAHİN M. G., Ozden T., ...More

Gazi Universitesi Eczacilik Fakultesi Dergisi, vol.12, no.1, pp.29-36, 1995 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 1995
  • Journal Name: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.29-36
  • Keywords: 2-(2-benzimidazolyl)-1-arylethylene, 2-methylbenzimidazole, antibacterial activity, antifungal activity
  • Gazi University Affiliated: Yes


2-Methylbenzimidazole as a starting material has been prepared by refluxing o-phenylenediamine with glacial acetic acid in hydrochloric acid for 6 hours according to the Phillps Method. 2-Styrylbenzimidazole derivatives have been synthesized by refluxing with 2-methylbenzimidazole and p-substituted arylaldehydes in acetic anhydride for 30 hours. Antimicrobial activities of the synthesized compounds have been tested against yeast-like fungi such as Candida albicans, Candida stellatoidea, Candida parapsilosis, Candida pseudotropicalis and Gram (+) microorganisms such as Staphylococcus aureus, Bacillus subtilis and Gram (-) microorganisms such as Escherichia coli, Pseudomonas aeruginosa.