Akademik Veri Yönetim Sistemi
Pharmaceutical Chemistry Journal, cilt.59, sa.9, ss.1048-1054, 2025 (SCI-Expanded, Scopus)
Obesity is a common health problem affecting all age groups and leading to many complications. In this study, the antiobesity (pancreatic lipasee enzyme inhibition), antihyperlipidemic (pancreatic cholesterol esterase enzyme inhibition), and antioxidant activities (DPPH radical scavenging effect, ferric reducing power and metal chelating capacity) of Cistus laurifolius aqueous and 80% methanol extracts were investigated. It was observed that the 80% methanol extract had higher antiobesity, antihyperlipidemic, and antioxidant activities than the aqueous extract. The inhibition of pancreatic lipase and pancreatic cholesterol esterase enzymes by 80% methanol extract was found to be 57.85 ± 1.20% and 63.70 ± 1.25%, respectively. The highest activity for antioxidant activity was observed at 1 mg/ml concentration (85.37 ± 0.21%) of 80% methanol extract in the DPPH radical scavenging effect assay. In this study, the inhibitory effects of Cistus species on pancreatic cholesterol esterase and pancreatic lipase enzymes were investigated for the first time. While the methanol extract showed a moderate effect in terms of pancreatic lipase enzyme inhibition, it inhibited pancreatic cholesterol esterase enzyme with a value (63.70 ± 1.25%) very close to the reference compound simvastatin (79.34 ± 3.89%). In addition, the amount of rutin, which is the major compound, was determined as 0.503 ± 0.001 g/100 g and 0.569 ± 0.001 g/100 g in aqueous and 80% methanol extracts, respectively, by the RP-HPLC method. Cistus laurifolius extracts are thought to be promising in terms of antiobesity and antihyperlipidemic effects.