Synthesis and antinociceptive activity of (1-benzyl-2(3H)-benzimidazolon-3-yl) acetic acid derivatives

Nacak S. , DOĞRUER D. S. , Sahin M.

FARMACO, vol.54, pp.768-772, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00100-7
  • Title of Journal : FARMACO
  • Page Numbers: pp.768-772


Eight (1-benzyl-2(3H)-benzimidazolon-3-yl)acetic acid derivatives have been synthesized and tested for antinociceptive activity in this study. All compounds but one, at the oral dose of 100 mg/kg were comparable with aspirin. Ethyl (1-benzyl-2(3H)-benzimidazolon-3-yl)acetate (3), 4-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]morpholine (6a) and 1-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]pyrrolidine (6b) have shown more potent antinociceptive activity than others. (C) 1999 Elsevier Science S.A. All rights reserved.