Simulation of glioblastoma multiforme (GBM) tumor cells using ising model on the Creutz Cellular Automaton

Zuleyha A., Ziya M., Selcuk Y., Kemal O. M., Mesut T.

Physica A: Statistical Mechanics and its Applications, vol.486, pp.901-907, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 486
  • Publication Date: 2017
  • Doi Number: 10.1016/j.physa.2017.05.096
  • Journal Name: Physica A: Statistical Mechanics and its Applications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.901-907
  • Keywords: GEM tumor, Cancer, Creutz Cellular Automata, Ising model, DIFFUSION-LIMITED AGGREGATION, GROWTH DYNAMICS, SOLID TUMOR, HYBRID, FRACTALS, CANCER
  • Gazi University Affiliated: Yes

Abstract

© 2017Computational models for tumors have difficulties due to complexity of tumor nature and capacities of computational tools, however, these models provide visions to understand interactions between tumor and its micro environment. Moreover computational models have potential to develop strategies for individualized treatments for cancer. To observe a solid brain tumor, glioblastoma multiforme (GBM), we present a two dimensional Ising Model applied on Creutz cellular automaton (CCA). The aim of this study is to analyze avascular spherical solid tumor growth, considering transitions between non tumor cells and cancer cells are like phase transitions in physical system. Ising model on CCA algorithm provides a deterministic approach with discrete time steps and local interactions in position space to view tumor growth as a function of time. Our simulation results are given for fixed tumor radius and they are compatible with theoretical and clinic data.