Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts

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Kosova F., Altan N., Sepici A., Engin A., Kocamanoglu N.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.114, sa.4, ss.183-188, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4149/bll_2013_039
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-188
  • Anahtar Kelimeler: diabetes mellitus, thyroid hormone, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA), ferrous oxidation in xylenol orange (FOX), SULFONYLUREA GLYBURIDE, GLUTATHIONE-PEROXIDASE, LIPID-PEROXIDATION, HYDROGEN-PEROXIDE, OXIDATIVE STRESS, CATALASE, TISSUE, ORANGE, LIVER
  • Gazi Üniversitesi Adresli: Evet

Özet

Free radicals, oxidative stress, and antioxidants have become commonly used terms in modern discussion of disease mechanisms. Accumulation of evidence suggests that toxic oxygen-derived reactive free radicals (superoxide, peroxide and hydroxyl radicals) play a crucial role in etiology of diabetes and its complication. Thus, it was aimed to determine the role of thyroid hormones in reversal of antioxidatant enzyme activities and lipid peroxidation alterations observed in experimentally induced diabetic rat hearts. The present study investigates the antioxidant enzyme activities such as SOD, CAT, GSH-Px and lipid peroxidation products in cardiac tissues of streptozotosin (STZ)-induced diabetic rats before and after thyroidectomy. Our results showed that CAT, GPx enzyme activities and FOX, MDA levels were increased (p<0.05) and SOD, Mn-SOD, Cu-SOD activities were decreased (p<0.05) during diabetes, hypothyroidism and hypothyroidism with diabetes, which can be regulated in different percentages with treatment of insulin and various doses of thyroid hormone (p<0.05). In conclusion, in this study, the possible contribution of thyroid hormones to the insulin effect of normalizing the induced diabetic changes in cardiac tissue and serum of rat has been seen (Tab. 5, Ref. 32). Full Text in PDF www.elis.sk.