Anti-ulcerogenic activity of some plants used as folk remedy in Turkey

Gurbuz İ., Ustun O., Yesilada E., Sezik E., Kutsal O.

JOURNAL OF ETHNOPHARMACOLOGY, vol.88, no.1, pp.93-97, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0378-8741(03)00174-0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-97
  • Keywords: anti-ulcerogenic activity, elaeagnus angustifolia, ethanol-induced ulcerogenesis, Hibiscus esculentus, histopathology, Papaver rhoeas, peptic ulcer, Phlomis grandiflora, Rosa canina, TRADITIONAL MEDICINE
  • Gazi University Affiliated: Yes


Five herbal remedies used as gastroprotective crude drugs in Turkey were assessed for anti-ulcerogenic activity using the EtOH-induced ulcerogenesis model in rat. The crude drugs investigated comprises fruits of Elaeagnus angustifolia L. (Elaeagnaceae), fresh fruits of Hibiscus esculentus L. (Malvaceae), fresh roots of Papaver rhoeas L. (Papaveraceae), leaves of Phlomis grandiflora H.S. Thomson (Lamiaceae) and fresh fruits of Rosa canina L. (Rosaceae). Extracts were prepared according to the traditional indications of use. Under our experimental conditions, all extracts exhibited statistically significant gastroprotective effect with better results for Phlomis grandiflora and Rosa canina (100%). At the concentration under study, both crude drugs were more effective than the reference compound misoprostol at 0.4mg/kg, Even the weakest anti -ulcerogenic effect observed for Papaver rhoeas roots was found statistically potent (95.6%). Histopathological studies confirmed the results of the in vivo test. (C) 2003 Elsevier Ireland Ltd. All rights reserved.