The main purpose of this paper is to research of the time-dependent hydrogen production possibility of the Laser Inertial Confinement Fusion Fission Energy (LIFE) engine using steam methane reforming (SMR), sulfur-iodine (S-I) thermochemical water splitting and high temperature electrolysis (HTE) cycles. The fuel zone of the LIFE engine contains 90 vol% Flibe coolant and 10 vol% TRISO coated minor actinides. Firstly, to examine the time-dependent hydrogen generation potential of this reactor, the time-dependent neutronic performance of the reactor has been performed with using the MCNP neutron transport code. As a result of neutronic calculations, tritium production (TBR), energy multiplication factor (M) and fuel burnup (BU) values have been computed. Secondly, the total power required for SMR, S-I and HTE cycle process have been calculated by using the time dependent energy multiplication factor obtained from the neutronic results. Depending on this total power, the change of hydrogen production with operation time in the LIFE engine has been investigated. As a result of the calculations, it has been found that the LIFE engine has a good both neutronic performance and hydrogen production by SMR, S-I and HTE cycle process. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.