A case of pediatric psoriasis achieving remission after allogenic bone marrow transplantation


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Güler D., Gürel G., Yalçın G. Ş. , Eker İ., Durusu İ. N. , Özdemir Ç., ...More

Turkish Journal of Pediatrics, vol.63, no.6, pp.1078-1083, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.06.017
  • Journal Name: Turkish Journal of Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1078-1083
  • Keywords: aplastic anemia, autoimmune, bone marrow transplantation, pediatric, psoriasis, STEM-CELLS, RESOLUTION
  • Gazi University Affiliated: Yes

Abstract

© 2021, Turkish National Pediatric Society. All rights reserved.Background. Psoriasis is an inflammatory skin disease in which the cells and molecules of innate and adaptive immunity are involved in the pathogenesis. Aplastic anemia is a bone marrow deficiency syndrome that is characterized by an extreme reduction in the number of blood cells as a result of failure in hematopoiesis. Allogenic hematopoietic stem cell transplantation is a promising treatment for Aplastic Anemia and it is important to note that other comorbid diseases like psoriasis-since both have some common pathogenetic mechanisims-might achieve remission after treatment. Case. We present a 12-years-old male patient who underwent bone marrow transplantation for aplastic anemia and his psoriasis vulgaris lesions completely regressed. The final follow-up visit on day 150 also revealed no sign of the pre-transplantation skin and scalp lesions. Conclusions. This is the first case of pediatric psoriasis together with aplastic anemia that achieved complete remission of psoriasis after bone marrow transplantation. Our case report needs to be supported by prospective studies involving larger patient populations.