Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis Siprofloksasin Profilaksisi Alan Lösemili Çocuklarda Febril Nötropeni için Risk Faktörlerinin Belirlenmesi ve Önleyici Stratejilerin Geliştirilmesi

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KAYA Z., Alıcı N., Kırkız S., KOÇAK Ü.

Turkish Journal of Hematology, cilt.40, sa.3, ss.183-186, 2023 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.4274/tjh.galenos.2023.2023.0116
  • Dergi Adı: Turkish Journal of Hematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.183-186
  • Anahtar Kelimeler: Children, Febrile neutropenia, Leukemia, Prophylaxis, Risk factor
  • Gazi Üniversitesi Adresli: Evet

Özet

The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.