Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis Siprofloksasin Profilaksisi Alan Lösemili Çocuklarda Febril Nötropeni için Risk Faktörlerinin Belirlenmesi ve Önleyici Stratejilerin Geliştirilmesi

Creative Commons License

KAYA Z., Alıcı N., Kırkız S., KOÇAK Ü.

Turkish Journal of Hematology, vol.40, no.3, pp.183-186, 2023 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.4274/tjh.galenos.2023.2023.0116
  • Journal Name: Turkish Journal of Hematology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.183-186
  • Keywords: Children, Febrile neutropenia, Leukemia, Prophylaxis, Risk factor
  • Gazi University Affiliated: Yes

Abstract

The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.