Neonatal hypoglycemia: A wide range of electroclinical manifestations and seizure outcomes


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Arhan E., Orturk Z., Serdaroglu A., Aydin K., Hırfanoğlu T., Akbas Y.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, sa.5, ss.738-744, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ejpn.2017.05.009
  • Dergi Adı: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.738-744
  • Anahtar Kelimeler: Neonatal hypoglycemia, Electroclinical, Outcome, Intractable epilepsy, Glucose, CEREBRAL INJURY, BRAIN-INJURY, EPILEPSY, NEWBORN, DAMAGE, ANTAGONIST, PATTERNS, GLUCOSE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: We examined the various types of epilepsy in children with neonatal hypoglycemia in order to define electroclinical and prognostic features of these patients. Method: We retrospectively reviewed the medical records of patients with a history of symptomatic neonatal hypoglycaemia who have been followed at Gazi University Hospital Pediatric Neurology Department between 2006 and 2015. Patients with perinatal asphyxia were excluded. Details of each patients perinatal history, neurological outcome, epilepsy details, seizure outcome and EEG and brain MRI findings were reviewed. Results: Fourty five patients (range 6 mo-15 y) with a history of symptomatic neonatal hypoglycaemia were included the study. Epilepsy developed in 36 patients and 23 of them had intractable epilepsy. All patients had occipital brain injury. Conclusion: We observed that most of the patients, either manifesting focal or generalized seizures, further develop intractable epilepsy. This finding establishes neonatal hypoglycemia as a possible cause to be considered in any case of intractable epilepsy. (C) 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.