Objectives: The purpose of this study was to evaluate the effect of the tooth color, ceramic color, and ceramic thickness on the final color parameters of a feldspathic computer-aided design (CAD)/computer-aided manufacturing (CAM) ceramic material. Materials and Methods: Resin specimens (12 x 14 x 4 mm) were prepared from six shades, namely, 0M1S, 1M1S, 2M3S, 3M2S, 4M3S, and 5M3S, to simulate tooth color. Ceramic slices with thicknesses of 0.3, 0.5, 0.7, and 1 mm were sectioned from Vitablocs Mark II (12 x 14 x 18 mm) in 10 shades-OM1C, 1M1C, 1M2C, 2M1C, 2M2C, 2M3C, 3M1C, 3M2C, 3M3C, and 4M2C. An intraoral spectrophotometer was used and three axes of Commission Internationale de l'Eclairage (CIE) LAB color space (CIE L* a* b*) and chroma (C) and hue (H) values were obtained. Results: The a* and b* values showed a decrease with increasing thickness. Generally, C decreased with the increasing ceramic thickness. The effect of ceramic thickness on H changed depending on the block and substructure color. The change of ceramic thickness resulted in changes in the lightness parameter (L*) of the ceramics. Generally, with an increase in the thickness, the L* value increased. The univariate analysis of variance (ANOVA) indicated a significant interaction between ceramic thickness and substructure color (P <. 005) and ceramic thickness and ceramic color (P <. 005). Conclusion: The final color parameters of a feldspathic CAD/CAM block were significantly affected by the changes in the ceramic thickness and substructure color.