Nanoantibiotics: A Novel Rational Approach to Antibiotic Resistant Infections

ENGİN A. B., Engin A.

CURRENT DRUG METABOLISM, cilt.20, sa.9, ss.720-741, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 20 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1389200220666190806142835
  • Dergi Adı: CURRENT DRUG METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.720-741
  • Anahtar Kelimeler: Nanoantibiotics, biofilm, blood-brain barrier, stimuli-responsive linkers, nanoparticle-based carriers, toxicity, targeted antimicrobials, MESOPOROUS SILICA NANOPARTICLES, COATED SILVER NANOPARTICLES, PSEUDOMONAS-AERUGINOSA, BIOFILM FORMATION, ANTIBACTERIAL ACTIVITY, DRUG-DELIVERY, OXIDATIVE STRESS, NITRIC-OXIDE, IN-VITRO, STAPHYLOCOCCUS-AUREUS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: The main drawbacks for using conventional antimicrobial agents are the development of multiple drug resistance due to the use of high concentrations of antibiotics for extended periods. This vicious cycle often generates complications of persistent infections, and intolerable antibiotic toxicity. The problem is that while all new discovered antimicrobials are effective and promising, they remain as only short-term solutions to the overall challenge of drug-resistant bacteria.