Protective effect of vitamin A on ARA-C induced intestinal damage in mice

Elli M., Aydin O., Bilge S., Bozkurt A., Dagdemir A., PINARLI F. G., ...More

TUMORI J, vol.95, no.1, pp.87-90, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1177/030089160909500114
  • Journal Name: TUMORI J
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.87-90
  • Keywords: cytarabine, mucosal damage, protection, mice, vitamin A, DEFICIENCY, TOXICITY, LEUKEMIA, ACIDS
  • Gazi University Affiliated: Yes

Abstract

Background. Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to investigate whether vitamin A (VA) can help prevent ARA-C-induced mucosal lesions in mice.