Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

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ARSLAN M., Comu F. M., Alkan M., Kiraz H. A., Kip G., Ozer A., ...Daha Fazla

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.116, sa.1, ss.47-50, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4149/bll_2015_009
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.47-50
  • Anahtar Kelimeler: erythrocyte deformability, myocardial ischaemia reperfusion, experimental diabetes, levosimendan, rat, DIABETES-MELLITUS, ANESTHETIC MANAGEMENT, MODEL, CHANNELS, DISEASE, AGENT, HEART, RATS, ATP
  • Gazi Üniversitesi Adresli: Evet

Özet

Diabetes mellitus (DM) is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischaemia-reperfusion (IR) injury is a cascade of events initiated by tissue ischaemia. The cellular damage produced by reperfusion leads to an active inflammatory response. Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of levosimendan on erythrocyte deformability during IR myocardial injury in diabetic rats.