Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

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ARSLAN M., Comu F. M. , Alkan M., Kiraz H. A. , Kip G., Ozer A., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.1, pp.47-50, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4149/bll_2015_009
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.47-50
  • Keywords: erythrocyte deformability, myocardial ischaemia reperfusion, experimental diabetes, levosimendan, rat, DIABETES-MELLITUS, ANESTHETIC MANAGEMENT, MODEL, CHANNELS, DISEASE, AGENT, HEART, RATS, ATP


Diabetes mellitus (DM) is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischaemia-reperfusion (IR) injury is a cascade of events initiated by tissue ischaemia. The cellular damage produced by reperfusion leads to an active inflammatory response. Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of levosimendan on erythrocyte deformability during IR myocardial injury in diabetic rats.