It is need that blood, vaccivation, serom and medicine should be existed specific condition so that it is kept without spoil. Portable Thermoelectric Medicine Kit towards this aim. It has a great importance with regard to either person or public health. According to the standards, prepared by World Health Organization (WHO), blood storage temperature should become between 2 degrees C and 10 degrees C. In this study, it is implemented electronic circuits of microcontroller controlled portable thermoelectric medicine kit can produce heat and cool. The inside temperature control of this medicine kit are set by two different method and compared results. The temperature control of this kit is realized with analog sensor and digital sensor. According to the comparisons, control system with digital temperature sensor saves more energy-saving than with analog temperature sensor.