Frequency of adiponectin gene polymorphisms in polycystic ovary syndrome and the association with serum adiponectin, androgen levels, insulin resistance and clinical parameters

Demirci H., Yilmaz M., ERGÜN M. A., YURTCU E., BUKAN N., Ayvaz G.

GYNECOLOGICAL ENDOCRINOLOGY, cilt.26, sa.5, ss.348-355, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/09513590903367051
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.348-355
  • Anahtar Kelimeler: PCOS, adiponectin gene polymorphisms, insulin resistance, androgens, adiponectin, TYPE-2 DIABETES-MELLITUS, ADIPOSE-SPECIFIC GENE, PLASMA ADIPONECTIN, WOMEN, OBESITY, RISK, SENSITIVITY, GLUCOSE, MUTATIONS, GENOTYPES
  • Gazi Üniversitesi Adresli: Evet

Özet

Materials and methods. Ninety-six patients with PCOS and 93 healthy control subjects were included in the study. Insulin resistance was estimated via HOMA-IR. Serum adiponectin levels were measured by ELISA. For determination of adiponectin gene polymorphisms, PCR was performed with appropriate primers after genomic DNA was obtained from the peripheral blood of the patients and control subjects.