Frequency of adiponectin gene polymorphisms in polycystic ovary syndrome and the association with serum adiponectin, androgen levels, insulin resistance and clinical parameters

Demirci H., Yilmaz M., ERGÜN M. A., YURTCU E., BUKAN N., Ayvaz G.

GYNECOLOGICAL ENDOCRINOLOGY, vol.26, no.5, pp.348-355, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.3109/09513590903367051
  • Journal Name: GYNECOLOGICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.348-355
  • Keywords: PCOS, adiponectin gene polymorphisms, insulin resistance, androgens, adiponectin, TYPE-2 DIABETES-MELLITUS, ADIPOSE-SPECIFIC GENE, PLASMA ADIPONECTIN, WOMEN, OBESITY, RISK, SENSITIVITY, GLUCOSE, MUTATIONS, GENOTYPES
  • Gazi University Affiliated: Yes

Abstract

Materials and methods. Ninety-six patients with PCOS and 93 healthy control subjects were included in the study. Insulin resistance was estimated via HOMA-IR. Serum adiponectin levels were measured by ELISA. For determination of adiponectin gene polymorphisms, PCR was performed with appropriate primers after genomic DNA was obtained from the peripheral blood of the patients and control subjects.