Improving the bioavailability and bioactivity of garlic bioactive compounds via nanotechnology


Lu X., Wang C., Zhao M., Wu J., Niu Z., Zhang X., ...More

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, vol.62, no.30, pp.8467-8496, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 62 Issue: 30
  • Publication Date: 2022
  • Doi Number: 10.1080/10408398.2021.1929058
  • Journal Name: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, CINAHL, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, SportDiscus, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.8467-8496
  • Keywords: Nanotechnology, garlic bioactive compounds, bioavailability, bioactivity, applications, SOLID LIPID NANOPARTICLES, DIALLYL-DISULFIDE DADS, PROSTATE-CANCER CELLS, HUMAN GASTRIC-CANCER, TRISULFIDE INDUCES APOPTOSIS, NEGATIVE BREAST-CANCER, OIL-IN-WATER, STERICALLY STABILIZED LIPOSOMES, MEDIATED MULTIDRUG-RESISTANCE, ALLYLMERCAPTO-L-CYSTEINE
  • Gazi University Affiliated: Yes

Abstract

This review highlights main bioactive compounds and important biological functions especially anticancer effects of the garlic. In addition, we review current literature on the stability and bioavailability of garlic components. Finally, this review aims to provide a potential strategy for using nanotechnology to increase the stability and solubility of garlic components, providing guidelines for the qualities of garlic products to improve their absorption and prevent their early degradation, and extend their circulation time in the body. The application of nanotechnology to improve the bioavailability and targeting of garlic compounds are expected to provide a theoretical basis for the functional components of garlic to treat human health. We review the improvement of bioavailability and bioactivity of garlic bioactive compounds via nanotechnology, which could promisingly overcome the limitations of conventional garlic products, and would be used to prevent and treat cancer and other diseases in the near future.