High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)

Koziol E., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Marcourt L., Budzynska B., Wolfender J., ...More

PHYTOMEDICINE, vol.54, pp.259-264, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2019
  • Doi Number: 10.1016/j.phymed.2018.10.030
  • Journal Name: PHYTOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.259-264
  • Keywords: Neurodegenerative disorders, Epilepsy, Zebrafish, Coumarins, Counter-current chromatography, Natural products, ANTICONVULSANT ACTIVITY, ZEBRAFISH, COUMARINS, CONSTITUENTS, FRUITS, CHOLINESTERASE, IMPERATORIN, INHIBITORS, DRUGS
  • Gazi University Affiliated: Yes


Background: Medicinal plants are a proven source of drug-like small molecules with activity towards targets relevant for diseases of the central nervous system (CNS). Plant species of the Apiaceae family have to date yielded a number of neuroactive metabolites, such as coumarin derivatives with acetylcholinesterase inhibitory activity or anti-seizure activity.