A sustained release dosage form of acyclovir for buccal application: An experimental study in dogs

Degim T., Eglen B., Ocak O.

JOURNAL OF DRUG TARGETING, vol.14, no.1, pp.35-44, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1080/10611860600566548
  • Title of Journal : JOURNAL OF DRUG TARGETING
  • Page Numbers: pp.35-44


Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for systemic uptake. Therefore, it was aimed to prepare a tablet for buccal administration and to investigate its effectiveness by performing in vitro and in vivo experiments.