A sustained release dosage form of acyclovir for buccal application: An experimental study in dogs

Degim T., Eglen B., Ocak O.

JOURNAL OF DRUG TARGETING, cilt.14, sa.1, ss.35-44, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/10611860600566548
  • Dergi Adı: JOURNAL OF DRUG TARGETING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.35-44
  • Gazi Üniversitesi Adresli: Hayır

Özet

Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for systemic uptake. Therefore, it was aimed to prepare a tablet for buccal administration and to investigate its effectiveness by performing in vitro and in vivo experiments.