Ghrelin, IGF-I and IGFBP-3 levels in children with type 1 diabetes mellitus

Bideci A., Camurdan M. O., Cinaz P., Demirel F.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.18, sa.12, ss.1433-1439, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1515/jpem.2005.18.12.1433
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1433-1439
  • Anahtar Kelimeler: ghrelin, IGF-I, IGFBP-3, children, type 1 diabetes mellitus, STIMULATES INSULIN-SECRETION, GROWTH-HORMONE SECRETAGOGUE, PLASMA GHRELIN, CIRCULATING GHRELIN, STOMACH, PEPTIDE, LEPTIN, RESISTANCE, RECEPTOR, GLUCOSE
  • Gazi Üniversitesi Adresli: Evet

Özet

There is a strong relationship between ghrelin, insulin, glucose and IGF-I/IGFBP-3 metabolism. This aim of this study was to investigate ghrelin level, and its relationship with IGF-I and IGFBP-3 levels in children with type 1 diabetes mellitus (DM1). Twenty-seven children with DM1 and 25 healthy controls were investigated. Ghrelin levels were similar, and IGF-I and IGFBP-3 levels were lower, in prepubertal and pubertal patients compared to controls. In the patient group, ghrelin levels were negatively correlated with chronological age, height, weight, pubertal status and IGF-I, but had no correlation with fasting glucose, HbA(1c), insulin dose, duration of insulin therapy, and IGFBP-3 levels. Similar ghrelin levels in patients compared to controls may suggest that ghrelin levels remain unchanged in children with DM1, or that altered ghrelin levels at diagnosis recover as a consequence of insulin therapy. The lack of correlation of serum ghrelin levels with fasting plasma glucose, HbA(1c) and insulin dose suggests that ghrelin level is not affected by these parameters. Decreased IGF-I level and its negative correlation with ghrelin are compatible with previous findings.