Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours

Yozgat A., KEKİLLİ M., Altay M.

World Journal of Clinical Cases, cilt.9, sa.29, ss.8627-8646, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 29
  • Basım Tarihi: 2021
  • Doi Numarası: 10.12998/wjcc.v9.i29.8627
  • Dergi Adı: World Journal of Clinical Cases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Sayfa Sayıları: ss.8627-8646
  • Anahtar Kelimeler: Enterochromaffm cells, 68Ga-DOTATATE, Gastrointestinal, Neuroendocrine tumours, Somatostatin receptor, Targeted peptide receptor radiotherapy, ZOLLINGER-ELLISON-SYNDROME, ENETS CONSENSUS GUIDELINES, ENDOCRINE NEOPLASIA TYPE-1, CLINICAL-PRACTICE GUIDELINES, GASTRIC CARCINOIDS, FOLLOW-UP, SURGICAL-MANAGEMENT, CHROMOGRANIN-A, SMALL-BOWEL, STATISTICAL EVALUATION
  • Gazi Üniversitesi Adresli: Hayır

Özet

© 2021 The Author(s). Published by Baishideng Publishing Group Inc. All Rights Reserved.Neuroendocrine tumors (NETs) are a rare and heterogeneous disease group and constitute 0.5% of all malignancies. The annual incidence of NETs is increasing worldwide. The reason for the increase in the incidence of NETs is the detection of benign lesions, incidental detection due to the highest use of endoscopic and imaging procedures, and higher recognition rates of pathologists. There have been exciting developments regarding NET biology in recent years. Among these, first of all, somatostatin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis, hormone secretion, and proliferation. Subsequently, activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism. Finally, the importance of proangiogenic factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblastic growth factor, angiopoietin, and semaphorins) in the progression of NET has been determined. Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment.