Activation of vocal fold healing with topical vitamin A in rabbits

Akdogan O., Selcuk A., Ozcan I., Ozcan K. M., Giray S. G., Dere H., ...Daha Fazla

ACTA OTO-LARYNGOLOGICA, cilt.129, sa.2, ss.220-224, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00016480802087219
  • Dergi Adı: ACTA OTO-LARYNGOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.220-224
  • Anahtar Kelimeler: Rabbit, vocal fold, vitamin A, acute healing, HEPATOCYTE GROWTH-FACTOR, INJECTABLE COLLAGEN, INJECTION
  • Gazi Üniversitesi Adresli: Evet

Özet

Conclusion. The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. Objectives. This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. Materials and methods. Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. Results. The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p0.01).