Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?

Tecer D., SEZGİN M., Kanik A., İNCEL N. A. , ÇİMEN Ö. B. , Bicer A., ...More

BIOMARKERS IN MEDICINE, vol.10, no.9, pp.967-974, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.2217/bmm-2016-0148
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.967-974
  • Keywords: C-reactive protein, Disease Activity Score 28, erythrocyte sedimentation rate, mean platelet volume, red cell distribution width, rheumatoid arthritis, INFLAMMATORY-BOWEL-DISEASE, FAMILIAL MEDITERRANEAN FEVER, PROGNOSTIC MARKER, HEART-FAILURE, PREDICTOR, ERYTHROPOIESIS, ASSOCIATION, BIOMARKERS, MORTALITY, INDICATOR
  • Gazi University Affiliated: Yes


Aim: To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). Patients & methods: Hundred RA and 100 controls were included. Results: MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 and 10.4. Patients with RDW >14.8 had higher Disease Activity Score 28 (DAS28; p = 0.002) and pain score (p = 0.0007). RDW was positively correlated with DAS28 and pain. But, DAS28 and pain were not different between patients with MPV >10.4 and <10.4. Conclusion: MPV and RDW were significantly higher in RA. RDW and MPV were similar to erythrocyte sedimentation rate and C-reactive protein to indicate inflammatory activity. RDW was correlated with pain and DAS28, but MPV was not associated with them.