Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?

Tecer D., SEZGİN M., Kanik A., İNCEL N. A., ÇİMEN Ö. B., Bicer A., ...More

BIOMARKERS IN MEDICINE, vol.10, no.9, pp.967-974, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.2217/bmm-2016-0148
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.967-974
  • Keywords: C-reactive protein, Disease Activity Score 28, erythrocyte sedimentation rate, mean platelet volume, red cell distribution width, rheumatoid arthritis, INFLAMMATORY-BOWEL-DISEASE, FAMILIAL MEDITERRANEAN FEVER, PROGNOSTIC MARKER, HEART-FAILURE, PREDICTOR, ERYTHROPOIESIS, ASSOCIATION, BIOMARKERS, MORTALITY, INDICATOR
  • Gazi University Affiliated: Yes

Abstract

Aim: To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). Patients & methods: Hundred RA and 100 controls were included. Results: MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 and 10.4. Patients with RDW >14.8 had higher Disease Activity Score 28 (DAS28; p = 0.002) and pain score (p = 0.0007). RDW was positively correlated with DAS28 and pain. But, DAS28 and pain were not different between patients with MPV >10.4 and <10.4. Conclusion: MPV and RDW were significantly higher in RA. RDW and MPV were similar to erythrocyte sedimentation rate and C-reactive protein to indicate inflammatory activity. RDW was correlated with pain and DAS28, but MPV was not associated with them.