The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study

Uzun L., Kokten N., Cam O. H., Kalcioglu M. T., UĞUR M. B., Tekin M., ...Daha Fazla

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.9, sa.4, ss.309-313, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.21053/ceo.2015.01032
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.309-313
  • Anahtar Kelimeler: Gentamicin, S-allylmercaptocysteine, Diallyl Disulfide, S-allylcysteine, Drug Toxicity, INDUCED OXIDATIVE STRESS, INDUCED LIVER-INJURY, AMINOGLYCOSIDE OTOTOXICITY, RENAL DAMAGE, RATS, CONSTITUENTS, EXTRACT, NEPHROTOXICITY, PREVENTION, MICE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objectives. Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. S-allylmercaptocysteine (SAMC), diallyl disulfide (DD), and S-allylcysteine (SAC) are three active compounds found in garlic. In this study, we investigated the effect of SAMC, DD, and SAC on the ototoxicity induced by gentamicin in rats, by using brainstem evoked response audiometry (BERA).