CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, vol.9, no.4, pp.309-313, 2016 (SCI-Expanded)
Article / Article
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Gentamicin, S-allylmercaptocysteine, Diallyl Disulfide, S-allylcysteine, Drug Toxicity, INDUCED OXIDATIVE STRESS, INDUCED LIVER-INJURY, AMINOGLYCOSIDE OTOTOXICITY, RENAL DAMAGE, RATS, CONSTITUENTS, EXTRACT, NEPHROTOXICITY, PREVENTION, MICE
Gazi University Affiliated:
Objectives. Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. S-allylmercaptocysteine (SAMC), diallyl disulfide (DD), and S-allylcysteine (SAC) are three active compounds found in garlic. In this study, we investigated the effect of SAMC, DD, and SAC on the ototoxicity induced by gentamicin in rats, by using brainstem evoked response audiometry (BERA).