The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study

Uzun L., Kokten N., Cam O. H., Kalcioglu M. T., UĞUR M. B., Tekin M., ...More

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, vol.9, no.4, pp.309-313, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.21053/ceo.2015.01032
  • Journal Name: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.309-313
  • Keywords: Gentamicin, S-allylmercaptocysteine, Diallyl Disulfide, S-allylcysteine, Drug Toxicity, INDUCED OXIDATIVE STRESS, INDUCED LIVER-INJURY, AMINOGLYCOSIDE OTOTOXICITY, RENAL DAMAGE, RATS, CONSTITUENTS, EXTRACT, NEPHROTOXICITY, PREVENTION, MICE
  • Gazi University Affiliated: Yes

Abstract

Objectives. Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. S-allylmercaptocysteine (SAMC), diallyl disulfide (DD), and S-allylcysteine (SAC) are three active compounds found in garlic. In this study, we investigated the effect of SAMC, DD, and SAC on the ototoxicity induced by gentamicin in rats, by using brainstem evoked response audiometry (BERA).